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Course module: SK-MBMSTC2
SK-MBMSTC2
Molecular and Cellular Life Sciences: Master Course Part 2 Molecular Recognition
Course info
Course codeSK-MBMSTC2
EC3
Course goals
Objectives:

1. To understand how protein structure correlates with protein function in selected biological systems. To appreciate how (changes in) protein structure lead(s) to (changes in) protein interactions (= molecular recognition) and how molecular recognition enables regulation of biological processes at the molecular level.

2. To become familiar with various techniques, including NMR and X-ray crystallography, to investigate the structure of biological macromolecules and with methods to predict and measure their interactions.

3. To know how to critically read a research article on structural biology by
a) Determining the research goal
b) Understanding the approach used or proposed (methodology/techniques)
c) Identifying the critical experiments
d) Getting the take-home message of the article or application
e) Proposing new research lines/experiments as follow-up or complementation
Content
Molecular recognition – the specific interaction between molecules - is at the basis of life.
To sustain life, molecules must engage in interactions at the right place and time and therefore molecular recognition must be tightly regulated. This course focusses on understanding molecular recognition at the atomic level.
 
The specific content of the course varies from year to year but includes lectures focusing on a biological system (e.g. cell adhesion in the blood circulation, complement system, chaperones) or an experimental or theoretical method (X-ray crystallography, nuclear magnetic resonance, recombinant protein expression, molecular docking). Short research lectures on several of these topics will be presented by PhD students or post-docs. In addition students will present and discuss research papers under supervision of one of the teachers and make one or two individual or group assignments.
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Kies de Nederlandse taal