After this course, the student understands the concepts of structure-based drug designand can apply this understanding to solve real problems with infective diseases, by designing a drug candidate based on target structure.
After finishing the student is able to:
- Systematically perform literature research critically
- Understand the structure and function of drug targets
- Understand the structure and function of small molecule drugs
- Explore the relationship between substituents and interactions
- Be able to predict physicochemical properties, like pKa, log P and log D
- Perform computational skills, like computer docking
- Understand the techniques to find and make new active molecules
- Present an unmet medical need
- Write a scientific report
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Are we in danger of falling back to the pre-antibiotic era? Can we deal with epidemics/pandemics of Ebola, Zika, Corona and Influenza virus? When will parasitic diseases like Malaria and Schistosomiasis be eliminated? What can you do yourself? These questions will be addressed in this course. A challenging assignment, to design a drug candidate against a disease of choice, forms the core of this course. The course is given entirely online, and at your own pace, so you can do it during your minor or major traineeship, even from abroad.
Subjects of the course are:parts of virology/bacteriology/parasitology/immunology, organic chemistry, biochemistry, pharmacology, pharmacokinetics, structural biology, and especially computational medicinal chemistry.
In this course, we challenge the student to think of a medical need, to find a target, to come up with a lead and to optimise this lead towards a drug candidate by means of molecular docking. You present the medical need and target in a prerecorded presentation and write a final report on your own drug candidate.
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