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Course module: BMB508612
BMB508612
Introduction to Regenerative Medicine and Technology
Course info
Course codeBMB508612
EC15
Course goals
After following this course, the student:
 
  • Understands the basics of regenerative medicine and technology. The student is acquainted with topics from the broad spectrum that makes up this field,
  • Can describe the development, tissue maintenance and pathology of specialized tissues and appreciate the rationale for regenerative medicine strategies.
  • Understands cell engineering techniques and (environmental) signaling strategies to improve cellular behavior in regenerative medicine.
  • Can describe cell matrix interactions and the mechanical properties of specialized tissues and apply these requisites to design a biomaterial to answer a specific research questions in the field of regenerative medicine and technology.
  • Can describe and distinguish between different in vitro, in vivo and ex vivo research models and techniques and determine which models/techniques can be used to answer a specific research or clinical diagnostic question.
  • Can develop a strategy from bench-to-bed to answer a specific research question.
  • Can describe the ethics of first-in-human (regenerative medicine) trials, for example with regard to the use of (stem) cells, bio-banking, participant selection and trial design.
  • Is able to perform a search for specific literature, is able to read research articles,
  • Is able to prepare, give and defend a short scientific presentation,
  • can give a critical appraisal of literature and presentations,
  • Knows which aspects are associated with writing a concise research proposal, including aspects of design of an experiment, statistics, ethics etc.,
  • Can identify and evaluate which challenges and approaches dominate frontier research of generation of various tissues,
  • Can function in multidisciplinary groups.
Content
Period (from – till): September 2017 - November 2017

Faculty
Lectures will be provided by course coordinators and guest lecturers from the UU, UMCU and TU/e. Working groups and tutorials will be administered by the guest lecturers and/or the course coordinators. Writing of research proposals will be supervised RM doctoral candidates from the UU, UMC and TU/e.

Description of content
The course will consist of a programme for 10 weeks, divided in 2 major blocks (A and B). This course provides the students with a broad overview and background in ‘Regenerative Medicine and Technology’. Lectures, assignments and group projects will prepare the students for research using tissue regeneration technologies.
 
The lay-out of the ten weeks will be as follows:
 
Week 1: ILS Introduction week of the Graduate School of Life Sciences including specific RMT intro
 
Weeks 2-7: Block A: Lectures, journal clubs and peer teaching with focus on molecular cell biology, stem cells, biomaterials, tissues (expert lectures), biomechanics and biofabrication. Also, an individual ethics assignment is part of this block before it will be concluded by an exam.
 
Weeks 8-10: Block B: Writing of research proposal (in small groups) and closing session with poster presentation.
 
Contact hours will be equally distributed between Eindhoven and Utrecht.
In block A, daily classes in the form of lectures, peer teaching, and discussions will cover basic regenerative medicine and technology topics from textbooks, e.g. organogenesis, embryogenesis, biomechanics and imaging techniques (for a more detailed description the student is referred to the block book). Self-study/preparation time for the journal clubs (on literature provided by the experts on their topic) and expert lectures. In addition to this, groups will write a short opinion article on an ethical issue in RM.
The group project in Block B consists of writing a research proposal that is aimed at the regeneration of a specific tissue (e.g. heart valve, cartilage). Information from block A will be incorporated into the research proposals under supervision of a tissue specific expert so that the student can directly apply the knowledge obtained. At the end of the block, the groups will present their proposal to representatives of the Regenerative Medicine and Technology program committee and each other in the form of a poster session.

Literature/study material used:


Study material for this course:
Block book (will be provided).
Principles of Regenerative Medicine (Second Edition 2011). Atala et al. Academic Press, Elsevier.
For the journal clubs/expert lectures, literature will be provided by the individual lecturers.
Optional: Biomechanics: concepts and computation by Oomens, Brekelmans and Baaijens (2009)
 
Registration:
Students of RMT will be automatically enrolled in this course. Please send an email to rmt@umcutrecht.nl before August 30th, 2017 to confirm your participation in the programme.
 
Mandatory for students in own Master’s programme:
Yes
 
Optional for students in other GSLS Master’s programme:
No
 
Prerequisite knowledge:
You must have a study entrance permit for RMT.
Note:      This is an overview course. If you notice that you are underqualified to understand what is taught at a particular part of the course, you should become acquainted through self-study or by following dedicated elective courses.
 
Pre-knowledge and/or self-study:
Molecular biology of the cell. Alberts et al, fifth edition (2007).
Principles of Regenerative Medicine (Second Edition 2011). Atala et al. Academic Press, Elsevier. Ch. 1,3,6,9,18,19
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