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Course module: BMB508212
BMB508212
Thrombosis and Haemostasis
Course info
Course codeBMB508212
ECTS Credits3
Category / LevelM (Master)
Course typeCourse
Language of instructionEnglish
Offered byFaculty of Medicine; Graduate School of Life Sciences; Biology of Disease;
Contact personJ.A. Korporaal
E-mailj.a.korporaal@umcutrecht.nl
Teaching period
MASTER  (21/08/2017 to 18/08/2018)
Teaching period in which the course begins
MASTER
Time slot-: Not in use
Study mode
Full-time
RemarkDate 13-24 Nov 2017. Apply at least 1 week before start of course. The maximum of participants is 30.
Enrolling through OSIRISNo
Enrolment open to students taking subsidiary coursesYes
Pre-enrolmentNo
Waiting listNo
Course goals
After completing the course, the student

1. is acquainted with the proteins and cells involved in thrombosis and haemostasis;
2. knows the main symptoms and underlying mechanisms of the diseases that are related to thrombosis and haemostasis;
3. can integrate biological principles of disease processes with their clinical manifestations;
4. can analyse and discuss a scientific report;
5. is acquanted with peer-review processes and is capable of reviewing the literature on actual themes in the thrombosis and haemostasis research field and also report on it;
6. is able to present data;
7. is able to devise new research in the field of one of the above mentioned diseases on the level of the junior-scientist;
8. is able to write a research proposal for a PhD-project in the field of thrombosis and haemostasis and describe experiments to address the proposed research questions;
9. can present and defend a research proposal in front of peers;
10. is able to critically read, listen and debate.
Content
Period (from – till): 13 November 2017 - 24 November 2017
 
Lectures:
Dr. J.A. Korporaal (coordinator) Department of Clinical Chemistry and Haematology, UMC Utrecht
Tel: 088-7556513 Email: J.A.Korporaal-3@umcutrecht.nl
Dr. R.T. Urbanus DLA, LKCH, UMC Utrecht
Dr. J.A. Korporaal DLA, LKCH, UMC Utrecht
            
Course description 
Haemostasis is an essential process in the prevention of blood loss as it facilitates undisturbed blood flow in the vasculature, resulting in the arrest of bleeding in response to injury of a blood vessel. Haemostasis consists of multiple components, including platelets, endothelial cells, and plasma proteins that together facilitate the coagulation cascade. Over the last 50 years, enormous progress has been made in understanding the role of platelets in haemostasis. Platelets circulate in blood in a resting state, but they are able to react immediately upon a vessel wall injury by adhering to the exposed collagen, followed by platelet-platelet interaction to form a plug that effectively seals the injured vessel wall to prevent excessive blood loss. Endothelial cells covering the vessel wall release inhibitors that prevent platelet aggregation, express proteins that inhibit the coagulation system, and synthesize components that stimulate the degradation of a fibrin clot. Similar to platelets, the coagulation system plays a crucial role in the maintenance of undisturbed blood flow. A hypo-active coagulation system will lead to a bleeding phenotype, while a hyper-active coagulation system increases the risk of thrombosis. Taken together, a well-balanced haemostatic system is thus essential for normal life. Inherited or acquired deficiencies may lead to an increased risk of bleeding or on the other hand to an increased risk of arterial and venous thrombosis.
The course will elaborate on the mechanisms responsible for the prevention of bleeding after injury (haemostasis) and the role of these mechanisms in the etiology of arterial and venous thrombosis. The biology of coagulation and the interaction between the vascular wall and circulating blood (cells) will be explained. In addition to basal biochemical sessions, the course will contain special sessions on therapeutic strategies, such as oral anticoagulants and thrombosis, state-of-the-art developments and valorization of laboratory tests, epidemiology of thrombosis, and biomarkers for thrombosis prediction. The students will train their knowledge of thrombosis and haemostasis in several work groups and students will get the opportunity to write a research proposal.

Literature/study material 
Will be provided at the course.

Registration
You can register via the study guide. The maximum number of participants is 30.
 
Mandatory:
Bod students with cardiovascular focus. For other BoD students: Four courses have to be chosen out of the six non-mandatory BOD-courses.
 
Optional for students from other programmes:
Yes. Admission of other students depends on their previous training.

Prerequisite knowledge
Bachelor BMW, Biology or other Life Sciences. Basic knowledge of thrombosis and haemostasis.
Entry requirements
Required materials
-
Instructional formats (attendance required)
Group assignment (Required)

Guest lecture (Required)

Individual (Required)

Instructional lecture (Required)

Lecture (Required)

Presentation (Required)

Private-study (Required)

Small-group session (Required)

Tests
Final result
Test weight100
Minimum grade5.5

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Kies de Nederlandse taal