After completing the module the student:
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knows the physico-chemical processes that determine the fate of chemicals in the environment;
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is able to perform fate calculations in order to estimate exposure concentrations in specific environmental compartments;
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knows the importance and complexity of sorption processes in determining exposure concentrations and understands the chemical processes underlying different sorption mechanisms;
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can explain that exposure is not determined by total but by bioavailable concentrations and can give examples of approaches to measure bioavailability in different settings;
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understands the processes playing a role in bioaccumulation and can perform and interpret bioaccumulation calculations;
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understands and can explain the processes playing a role in the internal distribution of chemicals;
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is acquainted with the principles of physiologically-based pharmaco-kinetic (PBPK) modeling;
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can work with and interpret the result of environmental fate models used to predict environmental exposure concentrations;
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knows the principles used in human exposure assessment (e.g. exposure routes, sensitivity and safety factor applications) of single chemicals and mixtures thereof.
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Period (from – till): 12 September 2016 - 23 September 2016
Lecturer(s)
Dr. Joop Hermens, DGK, IRAS/TOX
Prof. Martin van den Berg, DGK, IRAS/TOX
Course description
Accurate risk assessment of chemicals not only relies on detailed knowledge of effects (hazard assessment), but also on appropriate information about exposure concentrations. In this module, the processes determining exposure concentrations of toxic chemicals in the environment, organisms, and human beings will be discussed. Main focus is on exposure concentrations of toxic compounds for organisms in the environment and different approaches for measuring and modelling such concentrations will pass in review. Based on environmental characteristics, the students will be allowed to calculate actual exposure concentrations themselves with the help of different models in computer practicals. Because not all exposure-related topics can be presented, students (in small groups) will be given the opportunity to perform literature research on a topic of their own choice. The results will be presented to the group, such that all students will get familiar with many different topics.
Literature/study material used
A reader with relevant background reading, further information and PowerPoint presentations will be provided.
Mandatory
TXEH students
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge
Students should have a BSc in Biology, Biomedical Sciences, Medicine, Veterinary Medicine or Environmental Sciences.
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