General objectives
The objective of this course is to get acquainted with the principles of effect assessment and its role in risk assessment.
After completing this course the student:
- has gained understanding of the importance and complexity of effect assessment approaches in both toxicology and environmental epidemiology.
- is able to critically evaluate different effect assessment methods from both disciplines.
- is able to interpret and to critically evaluate scientific literature on effect assessment.
Specific objectives
After completing this course the student:
- is able to choose an appropriate epidemiological study design for a specific environmental health issue.
- Is able to apply regression analysis to environment and health data.
- knows issues concerning power, sensitivity, data quality, exposure misclassification, confounding, bias and selection effects and is able to determine their influence on outcomes of epidemiological studies.
- knows how (chemical) substances reach and act on the human body (i.e. toxicokinetics (ADME), including understanding the major pathways of metabolism.
- knows different types of toxicity (e.g. local/systemic, acute/chronic, single/repeat dose).
- knows different endpoints of toxicity (e.g., reversible/irreversible effects, mutagenicity, carcinogenicity).
- knows the toxicology of several individual organ systems including liver, kidney, central and peripheral nervous system, endocrine and reproductive system and immune system.
- knows how to deal with non‐linear dose‐response curves in health effect assessment.
- knows the concepts of threshold and non-threshold effects, and knows how these two concepts are applied in the derivation of health based standards (health criteria values).
- is able to perform a standard cytotoxicity test in an in vitro cell culture system
|
 |
|
Period (from – till): 11 October 2021 - 5 November 2021
Contact person:
Dr Mieke Lumens - m.lumens@uu.nl
Faculty:
Dr Gerard Hoek, IRAS/EEPI, DGK
Dr Mieke Lumens, IRAS/EEPI, DGK
Dr Remco Westerink, IRAS/TOX, DGK
Dr Raymond Pieters, IRAS/TOX, DGK
Dr Marianne Bol-Schoenmakers IRAS/TOX, DGK
PhD students and guest speakers
Course description:
Effect assessment is one of the major steps in risk assessment. One definition of effect assessment is: the combination of analysis and inference of possible consequences of the exposure to a particular agent based on knowledge of the dose-effects relationship associated with it in a specific target system. In this module effect assessment approaches in both toxicology and environmental epidemiology will be discussed.
Literature/study material used:
Relevant background information and PowerPoint presentations will be provided.
Registration:
You can register for this course via Osiris Student. More information about the registration procedure can be found here on the Studyguide.
Maximum number of participants is 30 students.
Mandatory for students in own Master’s programme:
Yes
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge:
You must have completed the bachelor exam, and have a strong background in toxicology and epidemiology.
|
|
|