The objective of this course is to get acquainted with the principles of effect assessment and its role in risk assessment.
General objectives
After completing this course the student:
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has gained understanding of the importance and complexity of effect assessment approaches in both toxicology and environmental;
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is able to critically evaluate different effect assessment methods from both;
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is able to interpret and to critically evaluate scientific literature on effect assessment.
Specific objectives
After completing this course the student:
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knows the basic principles, structure of, and advantages and disadvantages of the different epidemiological study designs;
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is able to choose an appropriate epidemiological study design in a given situation;
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knows the principles of regression analysis and is able apply these based on given data;
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knows issues concerning power, sensitivity, data quality, exposure misclassification, confounding, bias and selection effects and is able to determine their influence on outcomes of epidemiological studies;
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knows how (chemical) substances reach and act on the human body (i.e. toxicokinetics (ADME), including understanding the major pathways of metabolism;
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knows different types of toxicity (e.g. local/systemic, acute/chronic, single/repeat dose);
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knows different endpoints of toxicity (e.g., reversible/irreversible effects, mutagenicity, carcinogenicity);
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knows the toxicology of individual organ systems specifically, the liver, kidney, central and peripheral nervous system, endocrine and reproductive system and immune system;
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knows how to deal with non‐linear dose‐response curves in health effect assessment;
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knows the concepts of threshold and non threshold effects, and knows how these two concepts are applied in the derivation of health based standards (health criteria values).
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Period (from – till): 8 October 2018 - 2 November 2018
Faculty
Dr Gerard Hoek, IRAS/EEPI, DGK
Prof Bert Brunekreef, IRAS/EEPI, DGK
Dr Mieke Lumens, IRAS/EEPI, DGK
Dr Majorie van Duursen, IRAS/TOX, DGK
Dr Remco Westerink, IRAS/TOX, DGK
Prof Martin van den Berg, IRAS/TOX, DGK
Dr Raymond Pieters, IRAS/TOX, DGK
PhD students and guest speakers
Course description
Effect assessment is one of the major steps in risk assessment. One definition of effect assessment is: the combination of analysis and inference of possible consequences of the exposure to a particular agent based on knowledge of the dose-effects relationship associated with it in a specific target system. In this module effect assessment approaches in both toxicology and environmental epidemiology will be discussed.
Literature/study material used
A reader with relevant background information and PowerPoint presentations will be provided.
Registration
Apply via the studyguide. Please apply before September 24 th.
Mandatory for students in own Master’s programme:
Yes
Optional for students in other GSLS Master’s programme:
Yes
Prerequisite knowledge:
You must have completed the bachelor exam, and have background knowledge of toxicology and epidemiology.
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