Upon completion of the course, the student can:
• Explain the scientific concept and the multidisciplinary scope of mechanobiology, as well as its importance in human physiology and diseases.
• Specify the essential players in the interactions between the cell and its environment and understands their primary roles.
• Describe the mechanical response of cells and extracellular matrices and its structural underlying.
• Describe the various state-of-the-art experimental and computational approaches to dissect the principles behind cell–matrix interactions.
• Explain state-of-the-art techniques in mammalian genome editing.
• Independently identify and propose how dynamic cell–matrix interactions can be harnessed for rational design of biomaterials and to manipulate cell behavior in regenerative medicine applications.
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PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN.
Period (from-till): 15 November 2021 - 5 February 2022 - Quartiles 2, semester A, time slot B (- Mo 5-8, Th 9-10, We 1-4)
Faculty:
responsible lecturer: dr. N.A. Kurniawan
co-lecturer: dr.ir. T.F.A. de Greef
Information: Secr. Soft Tissue Biomechanics and Engineering - GEM-Z 4.115 – 2279
dr. N.A. Kurniawan - GEM-Z 4.102 – 2347
Course Discription:
Graduate-level course on cellular mechanobiology, covering principles behind physical changes in cell or tissue mechanics during physiology and disease, and how these can be harnessed in regenerative medicine.
•Introduction to mechanobiology
•Mechanosensing and mechanotransduction
•Cell and matrix mechanics
•Cellular and mammalian gene engineering approaches
•Biophysical manipulation
•Measurement techniques
•Reconstructing cell–matrix interactions
The course consists of 7 weeks independent learning under supervision in 2 blocks of 2 hours per week plus 7 weeks lecture in 2 blocks of 2 hours per week.
Literature/study material used:
Study guide
Lecture handouts
Introduction to Cell Mechanics and Mechanobiology, by Jacobs, Huang, Kwon (recommended)
Articles and possible other materials communicated before/during the course
Registration:
Register in Eindhoven with code 8MM40. Osiris registration will be done retroactively when results from the TU/e are received.
Max 60 students.
Mandatory for students in own Master’s programme:
No
Optional for students in other GSLS Master’s programme:
No, for RMTM students only.
Prerequisite knowledge:
Recommended:
8RB00 - Molecular cell biology
8TA00 - Cell and tissue
8TB00 - Continuum mechanics
8WC00 - Regeneration
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