Period:Quartile 3, timeslot A
Faculty
Responsible lecturer: dr. P.Y.W. Dankers
Information: Secr.Institute for Complex Molecular Systems - CE 1.31 - 2482
Co-lecturers:
dr. S. Hofmann Boss
dr. J.J.C. Arts
Visiting lecturer(s)
Course Discription
PLEASE NOTE THAT THIS COURSE IS TAUGHT IN EINDHOVEN
Interactions between (synthetic) biomaterials and tissues play a key role when a part of the body is replaced by an implant. At the surface of these implants (e.g. stents, sutures, hip prostheses, heart valves, blood vessels) molecular and microscopic processes determine their fate, so whether the implants ultimately fail or are successful.
This course will introduce you to different classes of biomaterials and will show you which processes play a role at the molecular level at the biomaterial-tissue interface.
Different (possible) subjects will be discussed which are listed below:
- History of biomaterials
- Classes of materials used in medicine
- Polymers, Ceramics, Metals, Biopolymers
- The extracellular matrix
- ECM-derived materials
- Biomaterial properties
- Mechanical properties
- Biocompatibility & host reaction to biomaterials
- In-vitro/in-vivo testing, Foreign Body Response - tissue response, Immune response, Inflammation, Wound healing, Complement system, Blood coagulation and blood-materials interactions, Biofilm formation and infections
- Processing of materials
- Electro-spinning, FDM, Gelation/cryo-gelation, Surface patterning
- Protein-biomaterial interactions
- Non-fouling surfaces
- Biomaterials for regenerative medicine/tissue engineering
- Cell/tissue-biomaterial interactions
- Bioactivation of biomaterials
- Self-assembled biomaterials
- Supramolecular chemistry
- Implants and devices
Literature/study material used:
Biomaterials Science - An Introduction to Materials in Medicine by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Third Edition, Elsevier, 2013 (recommended)
Besides the book Biomaterials Science by Ratner et al. we will discuss several articles from recent literature that will be handed out (or put on OASE) during the course.
Registration:
Please register at the TU/e, course code: 8SM20, and in Osiris.
Mandatory for students in own Master’s programme:
No.
Optional for students in other GSLS Master’s programme:
No.
Prerequisite knowledge:
8SA00 - Introduction Organic Chemistry (recommended)
8SC00 - Materials science (recommended)
8TA00 - Cell and tissue (recommended)
Additionally advised: Basic tissue engineering, Basic knowledge of materials science (mechanical properties, polymers), of simple chemical structures, and of cell behavior in tissues.
|