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Course module: BMB500503
BMB500503
Mechanisms of Disease
Course info
Course codeBMB500503
EC3
Course goals
After completing the course, the student:

1. is familiar with the use of medical terms;
2. knows the main symptoms and underlying mechanisms of the diseases that are discussed in this course: breast cancer, malignant melanoma or lymphoma, CHF: both dilated and concentric, heart valve disease, arrythmias, hepatitis C,
3. can explain the main characteristics of biological principles of disease e.g. cell-mediated toxicity, immune therapy in cancer, apoptosis, intercellular messengers (exosomes)
4. can explain the main principles of stem cell therapy and tissue engineering;
5. is acquainted with the basic aspects of translating laboratory tests into clinical investigation;
6. can integrate biological principles of disease processes with their clinical manifestations;
7. is able to devise new research in the field of one of the above mentioned diseases on the level of the junior-scientist;
8. is acquainted with peer-review process;
9. is able to present results;
10. is able to search literature databases;
11. is able to critically read, listen and debate.
Content
Period (from – till): 6 March 2017 - 17 March 2017.
 
Faculty
M.L. Zonderland, PhD, UMCU, DH&L, Med Physiology, coordinator, lecturer and supervisor
M.A.G. van der Heyden, UMCU, DH&L, Med Physiol, lecturer
T.P. de Boer, PhD, UMCU, DH&L, Med Physiology, lecturer
Prof C. Bouten, Ir A.I.P.M. Smits, PhD, TuEindhoven, Biomedical Engineering, lecturer
N. Bovenschen, PhD, UMCU, DLA, Pathology, lecturer, supervisor
Prof H.V.M. van Rijen, UMCU. Onderwijscentrum, lecturer
S. de Jong, PhD, lecturer, supervisor
prof A. de Bruin, Pathobiology,  Veterinary Medicine, lecturer
E.H.M. Nolte-'t Hoen, PhD Biochemistry and Cell Biology, Veterinary Medicine, lecturer
E.J. van der Vlist, PhD, supervisor
J.H.W. Leusen, PhD, LTI, UMC Utrecht

Course desciption 
The course aims to integrate the biological principles of disease processes with their clinical manifestations - the signs and symptoms which enable a diagnosis to be made. Clinical lectures (e.g. on chronic heart failure, valvular heart disease, cancer) and lectures on mechanisms of disease (ischemia, monoclonal Ab, exosomes, apoptosis) and therapy (e.g. stem cells, regenerative medicine, immune therapy, cell - mediated cytotoxic) are given. Students have to deliver a presentation on one of the diseases in which the aetiology, therapies and experimental models used to study these items are discussed. The course is concluded by a written exam.

Literature/study material 
  • Recent reviews and original articles;
  • Robbins: Pathologic Basis of Disease: parts of four chapters.
Registration
Apply at least 2 weeks before the start of the course via the study guide. The maximum of participants is 40.
 
Mandatory
For BoD students.

Optional for other GSLS Master's students:
Yes.

Prerequisite knowledge
BSc. in biomedical sciences including advanced knowledge of physiology and pathophysiology of organs and organ systems and of pathology.
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Kies de Nederlandse taal