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Course module: BMB404506
BMB404506
Bacterial Pathogenesis
Course info
Course codeBMB404506
EC3
Course goals
Learning goals:
After completing the course the student is able to:
 
  1. explain the principles of bacterial cell biology, including genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis;
  2. explain the concepts of prokaryotic cell signaling including chemotaxis / mortility, cell-cell signalling (quorum sensing, biofilms);
  3. describe bacterial virulence strategies, such as LPS synthesis and expression of carbohydrate receptors;
  4. describe bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival;
  5. explain the role of bacterial community with respect to intestinal flora and health;
  6. knows the key players of host cell defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus);
  7. knows mechanisms of action antibiotics and can explain how resistance against antibiotic treatment evolves by applying the knowledge about integrons, plasmids and efflux pumps;
  8. discuss cutting edge information about protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies and novel antibiotics/phage therapy.
  9. incorporate cutting edge information about bacterial pathogenesis in a state-of-the-art research proposal
Content
Period (from – till): 23 September 2019 – 4 October 2019
 
Course Coordinators
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine

Contact:
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht (E-mail: S.H.M.Rooijakkers@umcutrecht.nl)
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine  (E-mail: m.r.dezoete@uu.nl  ) 
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine (E.mail: k.strijbis@uu.nl )
I&I Secretariat (course registration & Osiris) (E-mail: secretary.iimaster@umcutrecht.nl)
 
Course description
By covering the following topics students will get the opportunity to expand their knowledge in the field of bacterial pathogenesis:
  • Bacterial Cell Biology: genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis
  • Prokaryotic Cell Signalling: chemotaxis / mortility, cell-cell signaling (quorum sensing, biofilms)
  • Bacterial Virulence Strategies: LPS synthesis, carbohydrate receptors
  • Bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival
  • Bacterial Community: intestinal flora and health
  • Host Cell Defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus)
  • Therapy & Resistance: mechanisms of action antibiotics, resistance mechanisms: integrons, plasmids, efflux pumps
  • Bacterial related disease: chronic inflammation, atheroscleroris, auto-immuno diseases and tumor formation
During tutorials students will present and discuss the following topics: protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies, novel antibiotics/phage therapy

Next to the written exam students are challenged to prepare an outline for their own grant proposal.
This will count for 10% of the final grade.

Literature/study material used:
All presented lectures and relevant journal references will be made available by BlackBoard and/or handouts. These materials form the basis of the course and are the subject of examination.

Registration:
Automatically after acceptance to the programme. Other students (only in exceptional cases) apply via studyguide. The maximum number of participants is 30.

Mandatory for students in own Master’s programme:
Yes

Optional for students in other GSLS Master’s programme:
Yes (only in exceptional cases)
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