| | Course code | | BMB404506 |
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Learning goals:
After completing the course the student is able to:
- explain the principles of bacterial cell biology, including genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis;
- explain the concepts of prokaryotic cell signaling including chemotaxis / mortility, cell-cell signalling (quorum sensing, biofilms);
- describe bacterial virulence strategies, such as LPS synthesis and expression of carbohydrate receptors;
- describe bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival;
- explain the role of bacterial community with respect to intestinal flora and health;
- knows the key players of host cell defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus);
- knows mechanisms of action antibiotics and can explain how resistance against antibiotic treatment evolves by applying the knowledge about integrons, plasmids and efflux pumps;
- discuss cutting edge information about protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies and novel antibiotics/phage therapy.
- incorporate cutting edge information about bacterial pathogenesis in a state-of-the-art research proposal
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Period (from – till): 24 September 2018 – 5 October 2018
Course Coordinators
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine
Contact:
Dr. Suzan Rooijakkers, Medical Microbiology, UMC Utrecht (E-mail: S.H.M.Rooijakkers@umcutrecht.nl)
Dr. Marcel de Zoete, I&I, Infection Biology, Vet. Medicine (E-mail: m.r.dezoete@uu.nl )
Dr. Karin Strijbis, I&I, Infection Biology, Vet. Medicine (E.mail: k.strijbis@uu.nl )
I&I Secretariat (course registration & Osiris) (E-mail: secretary.iimaster@umcutrecht.nl)
Course description
By covering the following topics students will get the opportunity to expand their knowledge in the field of bacterial pathogenesis:
- Bacterial Cell Biology: genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis
- Prokaryotic Cell Signalling: chemotaxis / mortility, cell-cell signaling (quorum sensing, biofilms)
- Bacterial Virulence Strategies: LPS synthesis, carbohydrate receptors
- Bacterial exploitation of host cell biology: mucosal cell entry, transcytosis, intracellular trafficking and survival
- Bacterial Community: intestinal flora and health
- Host Cell Defense: innate receptors, innate effectors (collectins, defensins, sIgA, mucus)
- Therapy & Resistance: mechanisms of action antibiotics, resistance mechanisms: integrons, plasmids, efflux pumps
- Bacterial related disease: chronic inflammation, atheroscleroris, auto-immuno diseases and tumor formation
During tutorials students will present and discuss the following topics: protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies, novel antibiotics/phage therapy
Next to the written exam students are challenged to prepare an outline for their own grant proposal.
This will count for 10% of the final grade.
Literature/study material used:
All presented lectures and relevant journal references will be made available by BlackBoard and/or handouts. These materials form the basis of the course and are the subject of examination.
Registration:
Automatically after acceptance to the programme. Other students (only in exceptional cases) apply via studyguide. The maximum number of participants is 30.
Mandatory for students in own Master’s programme:
Yes
Optional for students in other GSLS Master’s programme:
Yes (only in exceptional cases)
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