OSIRIS - Course offerings BMB403905 2016

Help

Course module: BMB403905

BMB403905

Biomolecular and Cellular Cardiology

Course info

Course code		BMB403905
EC		3

Course goals

After completing the course the student is familiar with:

1. the basic principles of heart structure, excitation and contraction;
2. the properties of cardiac gap junction channels and their role in action potential propagation;
3. the alterations in gap junction expression observed in cardiac disease and the functional consequences thereoff;
4. the structural, contractile and electrical remodeling processes occurring in the diseased heart and their role in the development of arrhythmias;
5. the structure, biosynthesis and function of microRNAs in general and the role they play in regulating gene expression in cardiovascular (patho)physiology;
6. the relation between altered adrenergic signaling and arrhythmias in cardiomyopathy;
7. the role of calcium and calcium-dependent proteins in the normal heart and changes in the abundance, function and regulation of these proteins related to cardiac disease;
8. the molecular basis of acquired and inherited arrhythmias;
9. different molecular, cellular and animal models used in the study of the healthy and diseased heart;
At the end of this course the student is also able, at an academic level, to:
10. work out a research assignment on a cardiovascular topic and describe experiments that will address the research question;
11. present and discuss the results of a research assignment in front of peers.

Content

Period (from – till): 28 November 2016 - 9 December 2016

Faculty
M.F.A. Bierhuizen, PhD, UMCU, DH&L, Med. Physiology, lecturer and coördinator/examinator
T.P de Boer, PhD, UMCU, DH&L, Med. Physiology, lecturer
M.B. Rook, PhD, UMCU, DH&L, Med. Physiology, lecturer
A. van Mil, PhD, UMCU, DH&L, Exp. Cardiology, lecturer
A.A.B. van Veen, PhD, UMCU, DH&L, Med. Physiology, lecturer
M.A. Vos, Professor, UMCU, DH&L, Med. Physiology, lecturer

Course description
The course aims to familiarize master students with different molecular and cellular approaches applied in the study of the healthy and diseased heart. Lectures will be given on various aspects of cardiac disease, such as alterations in microRNA expression, Ca2+ regulation, adrenergic signalling and gap junctional communication. Moreover, the molecular basis of arrhythmias (either inherited or acquired) will be featured from different view points as well. This theoretical part will be concluded with a written exam. Students will further have to work on an assignment on one of these subjects and present their results in both a written report and presentation.

Literature/study material used:
Recent reviews and original articles on the different topics.

Registration:
Apply at least 1 week before start of course. Register via the study guide. The maximum number of participants is 40.

Mandatory for students in own Master’s programme:
BoD students with cardiovascular focus; other BoD students have to follow 4 out of the 6 non-mandatory BoD courses.

Optional for students in other GSLS Master’s programme:
Yes.

Prerequisite knowledge
Basic understanding of cardiovascular physiology (level: Silverthorn's Human Physiology book, sixth edition) is expected.

Help